N,N-Dimethyltryptamine (DMT or N,N-DMT) is a chemical substance that occurs in many plants and animals and which is both a derivative and a structural analog of tryptamine. It can be consumed as a psychedelic drug and has historically been prepared by various cultures for ritual purposes as an entheogen. DMT is illegal in most countries. . It is the active hallucinogenic compound in ayahuasca, the Quechua name for a tea brewed from the shrub Psychotria viridis, which is used for ritual purposes by the indigenous people in the Amazon. See our ayahuasca guide for more on this psychedelic brew.
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The psychedelic threshold for DMT is about 0.2 mg/kg. When smoked, it’s a very fast-acting substance with peak subjective experience occurring around 2 minutes after ingestion, and completely resolving within 15 to 20 minutes.When taken as an ayahuasca brew, the effects can take up to an hour to appear, and may last for several hours.
A study in the 1990s examined the dose effects of intravenous DMT at 0.05, 0.1, 0.2 and 0.4 mg/kg in a double-blind, randomized design, using 12 volunteers. The Hallucinogen Rating Scale (HRS), that was developed and used for this study, grouped responses into six clinical categories: Affect, Volition, Somatic Effects (‘Somaesthesia’),Perception, Cognition, and Intensity.The ‘psychedelic’ threshold for DMT was at 0.2 mg/kg, at which most biological effects were also detectably altered. Adrenocorticotropin hormone, beta-endorphin, prolactin, growth hormone (GH) and cortisol were all elevated following DMT administration. Pupil diameter, heart rate, blood pressure and all peaked within 2 min as did subjective experiences.No evidence of tolerance (needing to take more for the same effect) for DMT was found in a later trial. NN DMT